Postdoctoral Researcher Position in South Korea – Cellular Immunology, Life Science at Department of Life Science, College of Natural Sciences, Hanyang University, South Korea
Postdoctoral Researcher Position – Cellular immunology
Deadline to Apply
Postdoctoral Researcher Position
No. of Position(s)
According to Standard Norms
Department of Life Science
College of Natural Sciences
PhD in relevant fields
Research in relevant fields and interests of the lab
How to Apply?
To apply, please click the Send E-mail button mentioned above.
Please provide the following:
- a cover letter presenting who you are and your scientific interests within the context of current research in our lab
- curriculum vitae
About the Choi Lab
The Choi’s Lab, also named as “Cellular Immunology Lab” is interested in the molecular and cellular basis of the immune response and immunomodulation in various diseases. Je-Min Choi, Ph.D., and his team study T lymphocytes regarding both how they contribute autoimmunity and how we could modulate their functions for therapeutics in human diseases.
T cells are originated from hematopoietic stem cells, matures in the thymus, and plays a central role in immune response. Although large variety of T cell clones are beneficial to fight against diverse pathogens, their possible reactivity to self-antigen should be tightly controlled by central and peripheral tolerance system. Thus, understanding of antigen specific T cell functions and immune tolerance is crucial to understand human diseases caused by abnormalities in immune system like autoimmunity, allergy, etc.
Dr. Choi and his laboratory have identified innate immunological function of CD4 T cells during inflammation in the spinal cord and brain in autoimmune encephalomyelitis model of mice. IL-1 and IL-23 was revealed to stimulate multi-clonal bystander activation of Th17 cells in antigen independent manner supporting large amount of IL-17 and GM-CSF to cause severe demyelination in CNS. They expand bystander T cell study to explain other diseases in a different circumstance of inflammation.
In addition, his team have discovered a tissue barrier-permeable peptide from human proteins to make successful intracellular delivery of T-cell modulatory molecules. By utilizing peptide-based drug delivery system, they developed fusion proteins or peptides combined to CTLA-4, PTPN, NFATi, NLRX1, siChi3l1, etc. to study its immunomodulatory roles in autoimmunity, allergy, graft rejection, and tumor immunity.
In particular, in vivo induction of Treg cells by CTLA-4 signaling peptide is major interest as to develop a peptide immune modulator as a novel therapeutic drug for treating autoimmune disease, allergy, transplantation, GvHD, etc.
- CNS autoimmune disease therapy by CTLA-4 signaling peptide
- Bystander T cell functions in autoimmunity, infection, and cancer
- Sex-differences in autoimmune diseases
- Tissue-barrier penetrating peptide and its application to modulate biological events
Department of Life Science, College of Natural Sciences, Hanyang University
#519 (Office), #527 (Lab), Natural Science Building, Hanyang University
222 Wangsimni-ro, Seongdong-gu, Seoul, 04763
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