Postdoc position in Pharmacogenomics – Aarhus University, Denmark

    Postdoc position in Pharmacogenomics - Aarhus University, Denmark

    Postdoc position in Pharmacogenomics of ADHD, in the Department of Biomedicine at Faculty of Health at Aarhus University (AU), Denmark


    Deadline to Apply

    June 01, 2021 (23: 59 GMT +1)


    Overview

    PositionPostdoc position
    No. of Position(s)1
    Research AreaPharmacogenomics 
    SalaryDKK 486,969.17 or 512,713.62 / Year
    WorkplaceDepartment of Biomedicine
    Faculty of Health
    Aarhus University (AU)
    Denmark
    Contract Period2 Years
    Starting dateSep 01, 2021

    Qualifications & Preference

    You have academic qualifications at PhD level, preferably within one or more of the following areas:

    • Strong experience in handling and analysing large genetic datasets.
    • Experience with high-performance computer clusters and/or cloud computing platforms.
    • Experience with GWAS, functional genomics and secondary GWAS bioinformatic analyses is expected, together with knowledge of programing languages.
    • Experience working with whole-exome sequencing data would be beneficial.
    • Great analytic and problem-solving skills.
    • Familiarity working with register data/electronic health records would be beneficial.
    • Excellent communication and writing skills.
    • Highly motivated, self-driven and with a strong background in statistical analyses in the field of genomics.

    Responsibilities/ Job Description

    As Postdoc in pharmacogenomics of ADHD your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues (both local and international) on your project, where you will receive supervision and guidance.

    Your main tasks will consist of:

    • Independent research of high international quality, including publication.
    • Work with data from the Danish registers (primarily the Danish Prescription Database) on servers at Statistics Denmark.
    • Perform statistical analyses of large-scale genetic datasets to identify genetic risk variants involved in ADHD medication discontinuation.
    • Perform analyses of the polygenic architecture of ADHD medication discontinuation including genetic correlation analyses and polygenic risk score analyses.
    • You will also be responsible for conducting secondary analyses using GWAS data, such as e.g. gene-set enrichment analyses and transcriptome-wide association studies based on imputed gene expression.
    • The position also entails teaching activities at the Faculty of Health including Medical Genetics course and supervision of medical students in research projects.

    How to Apply?

    To apply, please click the Apply Online button mentioned above

    Documents Required

    Your application must include the following:

    • Motivated application
    • Curriculum Vitae
    • Diploma
    • A list of publications
    • A teaching portfolio. We refer to Guideline on the use of teaching portfolios
    • A maximum of five of the publications of greatest relevance to the job may be submitted
    • Template for applicant – postdoc must be completed and uploaded under ‘Extra documents’
    • Strategic research plan can be uploaded
    • Coauthor statement(s) can be uploaded
    • References/recommendations can be uploaded separately in the e-recruitment system

    We refer to the faculty’s Guidelines for applicants.

    About Research project

    Stimulant medications are first line treatment for Attention Deficit Hyperactivity Disorder (ADHD) and have proven effective in reducing ADHD core symptoms and risk of several negative outcomes such as injuries, accidents and risk of substance use disorder. Despite this, ~50% of ADHD patients that initiate stimulants discontinue treatment within two years, with poor treatment response and side-effects being the most common reasons. The biological mechanisms underpinning medication discontinuation are not well understood, and the aim of this project is to identify common and rare genetic variants involved in ADHD medication discontinuation and elucidate the shared genetic architecture of medication discontinuation with cardiometabolic diseases. The project entails analyses of comprehensive genome-wide data generated by the iPSYCH consortium including more than 130,000 genotyped individuals (22K ADHD cases), which can be linked to information about ADHD medication use in the National Danish Prescription register.

    About the Department

    We offer a vibrant international research environment where English is the preferred language in the laboratory, at meetings and at seminars. The Department employs some 450 people and covers a range of research areas within Biomedicine. We contribute to the Bachelor’s degree programs in medicine, molecular medicine, odontology and the Master’s degree programs in biomedical engineering and medical chemistry. Our infrastructure is well developed with modern laboratories, core and animal facilities. You will work either in the brand new ‘Skou Building’ or similar as we are in the process of modernizing our old facilities. You can read more about the department here and about the faculty here.

    Terms of employment

    Inquiries

    Ditte Demontis Associate professor
    Department of Biomedicine
    Phone: +4528539746
    Email: ditte@biomed.au.dk

    HE Administrative Centre – Health HR
    Phone: +4521623283
    Email: emply.he.hr@au.dk

    Official advertisement

    Postdoc in pharmacogenomics of ADHD

    Post expires at 8:59am on Wednesday June 2nd, 2021 (GMT+9)