Postdoc position in Alzheimer’s Disease in Neuropharmacology and Genetics Lab, at the Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
Deadline to Apply
June 10, 2021 (23: 59 GMT +1)
|No. of Position(s)||1|
|Research Area||– Neuroscience|
– Natural sciences
– Medical sciences
|Salary||34,899,56 DKK / Month|
|Workplace||Neuropharmacology and Genetics Lab|
Department of Neuroscience
Faculty of Health and Medical Sciences
University of Copenhagen
|Contract Period||2 Years|
|Starting date||Sep 01, 2021|
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:
Essential experience and skills:
- You have a PhD in neuroscience or equivalent degree in natural or medical sciences
- You are highly experienced in rodent models of Alzheimer’s Disease, especially memory related tests
- You hold an animal experimentation licence
- You have an active interest in Alzheimer’s disease and its mechanisms
- Proficient communication skills and ability to work in teams
- Excellent English skills, both written and spoken
- Experience or knowledge with AAV vectors and its application in rodents
- Experience in handling, maintaining, genotyping and perfusion of rodents
- Experience in performing mouse behavioral tests, especially memory related tests
- Experience in cell culture, primary neuronal culture, and organotypic slice culture
- Experience with biochemistry, e.g. WB, ELISA, IP (preferable related to β-amyloid)
- Experience with molecular biology, such as plasmids and cloning
- Experience with histology techniques, immunocytochemistry and immunohistochemistry
- Experience in quantitative image analysis
All highly motivated and ambitious candidates, regardless of their personal background and status, are encouraged to apply.
Responsibilities/ Job Description
The postdoc will work with a novel gene therapy approach that ultimately aims at reducing β-amyloid (Aβ) deposition, a pathological hallmark and claimed disease target in AD, by targeting a yet “undruggable” protein, hereby circumventing classical pharmacological approaches, with the hope of finding new therapeutic means to prevent AD progression.
The work will among other techniques include in vitro and in vivo testing of AAV vectors in AD models, biochemistry, molecular cloning, and microscopy. In brief, the ideal candidate should be able to conduct independent and creative research within Alzheimer’s Disease and gene therapy, demonstrating scientific productivity, and good collaboration skills.
How to Apply?
Your online application must be submitted in English by clicking ‘Apply now’ above. Furthermore your application must include the following documents/attachments – all in PDF format
- Motivated letter of application (max. one page).
- CV incl. education, work/research experience, language skills and other skills relevant for the position.
- A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
- Animal experimentation licence (i.e. proof of education and training)
- A complete list of publications.
About Research project
The research focus of the group is on the development, invention and application of creative viral genetic tools to uncover new mechanisms of neuronal plasticity and animal behavior. This also includes exploring how viral gene therapy can be used for potential clinical application to address unmet needs in patients with neurological disorders.
Our most recent work is on reversing pain hypersensitivity by manipulating an unconventional target and target mechanism. Our strength is on the conceptual design and application of atypical recombinant peptides encoded by adeno-associated viral (AAV) vectors combined with behavioral assessments in WT and transgenic mice.
- The employment as postdoc is a full-time and fixed-term position for 2 years. Starting date is 1 September 2021 or after agreement. The position is sponsored by a grant provided by the Lundbeck Foundation. Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 34,899,56 DKK/ approx. 4,653 Euro (April 2021-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.
- Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).
- Interviews are expected to be held in week 26.
Post expires at 8:59am on Friday June 11th, 2021 (GMT+9)