Neuroscience – Postdoc position in stem cell-based modelling of schizophrenia, at Department of Neuroscience, University of Copenhagen, Denmark
Deadline to Apply
May 21, 2021 (23: 59 GMT +1)
|No. of Position(s)||1|
|Research Area||– Biology|
– Human Biology
– Data science
|Salary||According to standard norms|
|Workplace||Department of Neuroscience|
University of Copenhagen
|Contract Period||4 Years|
|Starting date||Sep 01, 2021l|
- Master’s degree related to the subject area of the project e.g. Biology, Biomedicine, Biotechnology, Human Biology, Bioinformatics/data science or similar
- PhD degree in the field of stem cell biology, brain development or schizophrenia research
- Fluency in English, written and spoken.
- Prior experience in hiPSC derivation
- Prior experience in pluripotent cell culturing and neural differentiation.
- Prior experience in working with neuronal cell cultures
- Prior experience in performing gene editing
- Prior experience in qRT-PCR, ICC and confocal imaging
- Prior experience in working with assessment of neuronal connectivity, synapse formation or neuronal function
- Works well in teams and collaborative projects
- Well-organized, self-motivated, result-oriented and capable of working independently
- Positive reviews from previous supervisors, collaborators or mentors
Responsibilities/ Job Description
We are seeking a highly motivated and ambitious postdoctoral candidate with a strong educational background in the field of biotechnology, biomedicine, biology or medicine and a PhD within the field of stem cell biology and/or schizophrenia research. The candidate will enter into a consortium research project aiming to study key protein networks involved in schizophrenia pathology through the use of complex human stem cell models of excitatory and inhibitory neurons. The candidate will during the project collaborate with other partners in the research consortium, including Prof. Kasper Lage of the Broad Institute and Prof. Thomas Werge from the Sct Hans Hospital of Mental Health. More information on the research consortium can be found here. The candidate will apply patient-derived iPSCs, CRISPR/Cas9 gene editing and complex neural culturing techniques to uncover how mutations in central GWAS-identified protein networks impact on neuronal function. The purpose of this work is to understand the link between gene mutations found in GWAS studies of schizophrenia patients and their mechanistic correlation to neuronal function and disease pathology.
Your key tasks are:
- Performance of an independent research project under supervision. Responsibility for daily supervision of PhD and master students will be possible.
- Participation in an active and ambitious research environment with a high degree of collaborative interactions between team members
The technologies you will apply are:
- Derivation of patient-derived iPSCs and validation of the quality of the cell lines
- Culturing and subtype-specific neural differentiation of hiPSCs and hESCs
- CRISPR/Cas9 gene editing in hiPSCs and hESCs to target key schizophrenia
- Assessment of neuronal subtypes in the dish through qRT-PCR and immunocytochemistry
- Assessment of neuronal function and connectivity through complex mixed neuronal cultures and microfluidic culturing plates
- Working with multi-electrode array chips for assessing neuronal network activity
- Performing single cell RNA sequencing (10X platform) and working with bioinformaticians on analysing the data
How to Apply?
Your application must be submitted electronically by clicking ‘Apply now’ above. The application must include the following documents in PDF format
- Motivated letter of application (max. one page)
- CV incl. education, experience from previous research projects, previous employments, technical skills, language skills and other skills relevant for the position + contact information of two references.
- Master of Science diploma and transcript of records.
- PhD diploma. If PhD is not completed, provide a written statement from the institution or supervisor stating that the PhD degree is expected in the coming months.
- Publication list
- Two reference letters
About Department of Neuroscience
The Human Neural Development research team is located at the Department of Neuroscience at the Faculty of Health and Medical Sciences of University of Copenhagen. Our group works to develop stem cell transplantation therapies for brain disorders such as Parkinson’s Disease, dementia and narcolepsy by producing high-purity cultures of subtype-specific human neural cells in the lab and testing these in animal models of disease. We further apply advanced stem cell technologies to study normally inaccessible stages of human brain development as well as to produce models of human brain diseases in the dish (i.e. Parkinson’s Disease, Schizophrenia and hypothalamic disorders).
We offer creative and stimulating working conditions in a dynamic and highly international research environment. Our team currently consists of 14 team members at University of Copenhagen + 4 team members in our sister group at Lund University, coming from 8 different nationalities. Our research facilities at University of Copenhagen are located in a new and modern research building from 2018, and include state-of-the-art laboratories, pleasant office facilities and access to high-quality core facilities in transcriptomics, imaging, flow cytometry and proteomics.
The successful candidate will be offered a full-time position for a total of 4 years as a postdoctoral fellow. Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organization.
The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of 19 December 2019. In addition to the basic salary, a monthly contribution to a pension fund is added (17.1% of the salary). Candidates from abroad may be eligible to reduced tax payment, according to the Special Tax Scheme for Researchers. More information about this can be found here: https://ufm.dk/en/research-and-innovation/cooperation-between-research-and-innovation/researchers-mobility/the-special-tax-scheme-for-researchers
Associate Professor Agnete Kirkeby
Department of Neuroscience
Phone: +45 5168 5353
Post expires at 8:59am on Saturday May 22nd, 2021 (GMT+9)