Postdoc position in Denmark – Molecular Metabolism, UCPH

    Postdoc position in Denmark - Molecular Metabolism, UCPH

    Postdoc position is available “to determine the role of this posttranslational modification (PTM) for maintaining cellular glucose homeostasis and insulin action“,  at the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), University of Copenhagen. Denmark

    Postdoc in Molecular Metabolism – Treebak Group (readvertisement)


    Deadline to Apply

    June 9, 2021 23:59 (GMT +1)


    Position

    Postdoc position

    No. of Position(s)

    1

    Research area

    • Biology
    • Biochemistry
    • Molecular Biology
    • Molecular Biomedicine
    • Mass spectrometry
    • Bioinformatics 

    Salary

    According to standard norms

    Workplace

    Novo Nordisk Foundation Center for Basic Metabolic Research
    University of Copenhagen
    DK-2200 Copenhagen, Denmark

    Contract period

    Three Years

    Inquiries

    Associate Professor Jonas Treebak
    Email: jttreebak@sund.ku.dk

    CBMR International Postdoctoral Program
     Email: cbmr@sund.ku.dk

    HR
    Email: sund-hr-cbmr@sund.ku.dk

    Qualifications

    PhD in Biology, Biochemistry, Molecular Biology, Molecular Biomedicine, or related sciences

    Preference

    • Excellent scientific track record in relation to career stage
    • Experience in the study of animal physiology, specifically related to in vivo and in vitro metabolic studies using transgenic and knockout models
    • Experience with cell cultures
    • Prior experience in research fields related to insulin signalling/sensitivity and/or ADP-ribosylation would be a clear advantage
    • An analytical aptitude for devising innovative scientific or technical solutions
    • Prior experience in high-resolution mass spectrometry is not essential, but will be considered an advantage
    • Knowledge in bioinformatics and large-scale data analysis, and skills in statistical computational environment such as R and Python will be considered a distinct advantage, but not a requirement
    • The candidate should be able to conduct independent and creative research, demonstrate scientific productivity, and show good inter-personal and communication skills
    • Strong motivation and excellent scientific skills are essential
    • Excellent English communication skills, both written and oral

    Responsibilities/Job Description

    Insulin resistance in peripheral tissues such as skeletal muscle and adipose tissue is characterized by an inability of the target tissue to appropriately modulate glucose disposal in response to a specific level of insulin. Insulin resistance precedes the development of type 2 diabetes (T2D) and is a consequence of ectopic lipid deposition in insulin responsive tissues. NAD+ has emerged as an important cofactor linking energy status with adaptive cellular and organismal responses, and it serves as a substrate for multiple enzymes involved in the regulation of energy metabolism. Low cellular NAD+ levels could therefore prompt the development of many age-related disorders, including insulin resistance. Skeletal muscle act as an important sink for glucose clearance under insulin-stimulated conditions, and insulin signaling to glucose disposal in skeletal muscle in the context of insulin resistance has been studied intensively over many years. We have preliminary data from quantitative mass spectrometric analysis of skeletal muscle that shows key proteins in the insulin signaling cascade are ADP-ribosylated. Since ADP ribosylation (ADPr) is mediated by NAD+-consuming ADP-ribosyltransferases, this indicates a yet unrecognized interplay between insulin signaling and cellular NAD+ metabolism. Our hypothesis is that ADPr plays an essential role in regulating insulin sensitivity in skeletal muscle, and our over-arching aim is to determine the role of this posttranslational modification (PTM) for maintaining cellular glucose homeostasis and insulin action. Your tasks would be to define and compare insulin-induced ADP ribosylomes of insulin sensitive and resistant skeletal muscle, and to identify key modifications that are important for insulin signaling to mediate glucose disposal. We strive to understand the molecular basis for ADPr in skeletal muscle insulin resistance, and we are looking for candidates who are motivated to integrate approaches in in vivo physiology, high-resolution mass spectrometry-based proteomics, and molecular biology.

    How to Apply?

    Your online application must be submitted in English via the ‘Apply now’ link above. Furthermore, your application must include the following documents/attachments – all in PDF format

    Documents required

    • Cover letter expressing the motivation and previous research experience of the applicant (max 1 page)
    • Curriculum vitae
    • Copy of the PhD degree certificate and the Master degree certificate. In case the PhD has not yet been completed, a written statement from the supervisor confirming it will be obtained before October 1, 2021 is acceptable.
    • List of publications
    • References (name and contact details of at least two references)

    About Novo Nordisk Foundation Center for Basic Metabolic Research

    The Novo Nordisk Foundation Center for Basic Metabolic Research’s vision is to strengthen interdisciplinary research that transforms our basic understanding of the mechanisms that underlie metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. We were established in 2010 and in 2017, we moved into new laboratories, offices and meeting rooms in the Maersk Tower

    The Center has around 240 employees who work in an international, highly collaborative research environment across a range of biomedical disciplines

    Note:

    • Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.
    • Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

    Other Postdoctoral Positions

    Post expires at 8:59am on Thursday June 10th, 2021 (GMT+9)