Postdoc position in Molecular biology, Medicine, Bioinformatics

    Postdoc position in Molecular biology, Medicine, Bioinformatics

    Molecular biology – Postdoc position in colorectal cancer genomics and circulating tumor DNA research, in the Department of Clinical Medicine at Faculty of Health at Aarhus University, Denmark


    Deadline to Apply

    June 18, 2021 (23: 59 GMT +1)


    Overview

    PositionPostdoc position
    No. of Position(s)1
    Research Area– Molecular biology
    – Medicine
    – Bioinformatics
    SalaryDKK 486,969.17 or 512,713.62 / Year
    WorkplaceDepartment of Clinical Medicine
    Faculty of Health
    Aarhus University
    Denmark
    Contract Period3 Years
    Starting dateSep 01, 2021

    Qualifications

    • You have academic qualifications at PhD level or are about to have, preferably within one or more of the following areas molecular biology, medicine, bioinformatics or similar.
    • You have research experience in genomics, and/or epigenomics and/or circulating cell free DNA as well as experience with next generation sequencing
    • You are rich in initiative, have a strong motivation for research and you have published peer-reviewed articles in international journals

    Preference

    • It is an advantage if you have experience with R, Python or similar programming languages and knowledge about colorectal cancer and/or cancer biology and experience with cancer genomics. Further, experience in medical statistical data analysis (using STATA, R or similar) will also be considered an advantage.
    • As a person, you are ambitious, take ownership and possess good collaborative, communication and interpersonal skills. We expect you to be fluent in oral and written English.

    Responsibilities/ Job Description

    As Postdoc in MOMA your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance.

    Your main tasks will consist of:

    • Independent research of high international quality, including publication.
    • Participation in daily operation of the trials, including lab work and support of the lab technicians
    • Participation in the weekly analysis of the newly generated tumor/normal whole exome sequencing datasets to identify the somatic genomic alterations that can serve as patient specific biomarkers for detection of ctDNA in the serial blood samples collected in the trials.
    • Optimizing, and potentially developing a new, bioinformatic pipeline for assessing clonality of the somatic genomic alterations identified by whole exome sequencing tumor/normal DNA sequencing.
    • Participation in the group’s effort to develop new strategies and approaches for detection of circulating tumor DNA, including approaches based on whole genomes sequencing (incl. lab work)
    • Develop independent and innovative research projects of high international quality within the field of cancer genomics and circulating tumor DNA.
    • Publication of research findings in top-tier peer-reviewed journals
    • Supervision of Bachelor-, Master- and PhD-students
    • Some degree of contribution towards attracting external research funding.

    How to Apply?

    To apply, please click the Apply Online button mentioned above

    Documents Required

    Your application must include the following:

    • Motivated application
    • Curriculum Vitae
    • Diploma
    • A list of publications
    • A teaching portfolio. We refer to Guideline on the use of teaching portfolios
    • A maximum of five of the publications of greatest relevance to the job may be submitted
    • Template for applicant – postdoc must be completed and uploaded under ‘Extra documents’
    • Strategic research plan can be uploaded
    • Coauthor statement(s) can be uploaded
    • References/recommendations can be uploaded separately in the e-recruitment system

    We refer to the faculty’s Guidelines for applicants.

    About Research project

    As Postdoc you will join the team handling the cancer genomics and ctDNA analyses of the ongoing ctDNA based interventional clinical trials IMPROVE, IMPROVE-IT and IMPROVE-IT2 (clinicaltrials.gov NCT03637686, NCT03748680, NCT04084249). Together the trials cover ~1,800 patients. From each patient we have whole exome sequencing data from matched tumor/normal DNA pairs, and ultra-deep digital-PCR or targeted sequencing data from serial blood samples.

    About the Department

    The colorectal cancer group develops and pioneers new approaches for non-invasive molecular diagnostics for cancer, primarily based on next-generation sequencing (NGS) of circulating cell-free tumor DNA (ctDNA). Led by Professor Claus Lindbjerg Andersen and a team of experienced translational genomics scientists, the lab studies large collections of plasma and other samples from cancer patients through an extensive portfolio of clinical studies and collaborations. We develop NGS analysis tools spanning genome-wide and targeted methods for sensitive detection of tumor-derived nucleic acids and aim to progress these into clinical use by proof-of-concept translational studies to demonstrate their utility. We further explore the biophysical properties of ctDNA to study its origins and interactions and to inform the development of increasingly sensitive methods. The group is a dynamic mix of molecular biologists, bioinformaticians and clinical fellows providing a unique environment for development and learning in cancer genomics and translational research, with a strong focus on clinical application.

    Note

    Inquiries

    Claus Lindbjerg Andersen
    Professor, Department of Clinical Medicine – Department of Molecular Medicine (MOMA)
    Phone: +4578455319
    Email: cla@clin.au.dk

    HE Administrative Centre – Health HR
    Phone: +4520681396
    Email: semply.he.hr@au.dk

    Official advertisement

    Three-year postdoc in colorectal cancer genomics and circulating tumor DNA research

    Post expires at 8:59am on Saturday June 19th, 2021 (GMT+9)