Molecular biology jobs – Postdoc position in the field of vascular biology and inflammation, The Department of Biomedicine at the Faculty of Health at Aarhus University, Denmark
Deadline to Apply
Apr 05, 2021 (23: 59 GMT +1)
|No. of Position(s)||1|
|Research Area||Molecular biology, Biochemistry, Molecular pharmacology, Vascular biology, Inflammation|
|Salary||DKK 486,969.17 to 512,713.62 / Annum|
|Workplace||Department of Biomedicine, Aarhus University, Denmark|
|Contract Period||3 Years|
- You hold a Ph.D. degree in molecular biology, biochemistry, molecular pharmacology or closely related disciplines
- You have extensive cell culture experience, including the handling of human endothelial cells, adipocytes, macrophages, lymphocytes, and/or fibroblasts
- You will be responsible for performing a wide range of research experiments in the area of molecular biology and cellular biology (cell culture, transfection, infection, cellular assays, FACS sorting/analysis)
- You have experience working with mouse models (tumor inoculation, measurements, drug treatments, standard dissections, and surgery)
- You have a proven scientific track-record, a thorough understanding of vascular biology and inflammation, and preferably tumor and/or adipose tissue biology.
- Your experimental skills probably cover cell-based assays, immunoassays, biochemical and gene expression analyses
- Post-doctoral experience within computation data analysis will be a strong advantage
- You have academic qualifications at the PhD level, preferably within one or more of the following areas: vascular biology, immunology, imaging, animal mouse models, and a strong interest in metabolism and recent developments in single cell omics technology
- Applicants with previous documented experience in data-mining are especially encouraged to apply.
- You possess a “can do” attitude with the ability to handle and prioritize multiple tasks and work well under pressure. As a person, you are ambitious, take ownership, and possess good communication and interpersonal skills.
- You will be expected to participate in postdoctoral research grant preparations, manuscript writing, and the presentation of research results at professional conferences. You should have solid analytical thinking, creativity, and a visible publication record. We expect you to be fluent in oral and written English.
Responsibilities/ Job Description
The Angiogenesis and Inflammation group headed by Assistant Professor Joanna Kalucka is looking for an outstanding postdoc to explore the underlying mechanisms of how the blood vessels respond to the tissue microenvironment and how their properties change in response to inflammation (e.g. in cancer or obesity). Using state-of-the-arttechnologies (scRNA-seq; proteomics, metabolomics), our group aims to develop new and improved diagnostic, prognostic, and therapeutic tools to detect endothelial cell dysfunction. The overall goal of the proposed project is to explore one of the targets/pathways previously identified by large-scale-omics analyses of human tumor and adipose tissues. You will explore the biology of one recently discovered candidate protein, which we have found to play a key role in endothelial cell activation and modulation during inflammation. You will further evaluate this candidate as a desirable drug target with respect to various alternative possibilities of targeting this pathway in metabolic control. More specifically, the project will be based on characterization studies in murine models in vivo and in vitro, utilizing relevant models for mimicking vascular activation and inflammation, as well as metabolic models of obesity and diabetes, combined with modulation of the expression of this target. The project will be conducted in a multidisciplinary environment at the interface of academia and a clinical environment, where resources and expertise in animal surgery and clinical patient material processing will be available. Excellent experimental methodological skill and dedication are necessary for successfully conducting the project.
Based on our preliminary results, you will further develop your own project in the area of endothelial cell dysfunction in obesity and/or cancer, with a particular aim to identify new regulatory nodes in the control of endothelial cell dysfunction and angiocrine signaling. You will collaborate with other members of the laboratory and with collaborators at the institute, and you will be expected to develop expertise in areas necessary for successful progress of your project. As a Postdoc in vascular biology and inflammation, your position is primarily research-based, but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance. The work related to the project will take place at the Department of Biomedicine, and the successful candidate will be integrated into the department.
How to Apply?
To apply, click the “Apply Online” button mentioned above
Your application must include the following:
- Motivated application
- Curriculum Vitae
- A list of publications
- A teaching portfolio. We refer to Guideline on the use of teaching portfolios
- A maximum of five of the publications of greatest relevance to the job may be submitted
- Template for applicant – postdoc must be completed and uploaded under ‘Extra documents’
- Strategic research plan can be uploaded
- Coauthor statement(s) can be uploaded
- References/recommendations can be uploaded separately in the e-recruitment system
We refer to the faculty’s Guidelines for applicants.
About the Group
The Kalucka group was recently established at the Department of Biomedicine at Aarhus University, with the goal of exploring basic functions of endothelial cells in health and disease (especially in cancer and obesity). We combine molecular biology approaches with the available state-of-the-arttechnical resources at the Department of Biomedicine. We are particularly interested in looking at the intersection of endothelial cell dysfunction and inflammation. Along these lines, the vacant projects will explore interactions of immune and endothelial cells, investigating their roles in the progression inflammation-related diseases.
The laboratory is equipped with the wide range of expertise and skills required to manipulate and probe the transcriptome/epigenome (and the mechanisms governing functions and phenotype of the endothelial cells). These resources span human tissues and mouse animal models, single cell sequencing (10x Genomics) RNA-seq, proteomics and metabolomics. You will receive extensive training and support in these areas. Through our excellent local and international collaborators and core facilities, you will have access to additional expertise and tools. The laboratory is well-funded and is located in one of the most dynamic research environments at Aarhus University.
We offer a vibrant international research environment where English is the preferred language in the laboratory, at meetings, and in seminars. The Department employs some 450 people and covers a range of research areas within Biomedicine. We contribute to the Bachelor’s degree programs in medicine, molecular medicine, odontology and the Master’s degree programs in biomedical engineering and medical chemistry. Our infrastructure is well developed with modern laboratories, core and animal facilities. You will work in the brand new ‘Skou Building’ located at the heart of the university campus, as well as at Steno Diabetes Center Aarhus, located at Aarhus University Hospital Skejby. You can read more about the department here and about the faculty here.
- Appointment as a postdoc requires academic qualifications at PhD level.
- Further information on the appointment procedure can be found in the Ministerial Order on the Appointment of Academic Staff at Universities.
- The appointment is in accordance with the Danish Confederation of Professional Associations (Akademikerne).
- Remuneration is in accordance with the above, and the Salary agreement catalogue for staff at Health.
- The yearly base salary for a fulltime postdoc position with minimum 3 years of working experience after achieved MSc degree is DKK 486,969.17 or DKK 512,713.62 with minimum 4 years of working experience after achieved MSc degree. The base salary includes a position related supplement and pension (17.1 %). Additional supplement(s) for special qualifications can be negotiated. Authorisation supplemement(s) will be granted, if relevant for the position. Your local eligible trade union representative at Aarhus University negotiates your salary on your behalf.
Assistant Professor Joanna Kalucka
Tel.: (+45) 52169817
HE Administrative Centre – Health HR
Post expires at 8:59am on Tuesday April 6th, 2021 (GMT+9)