CMBR Postdoc Program – Molecular Biology, Biochemistry, Biomedicine, Metabolic Research is available to determine the mechanism by which energetic stressors converge on AMPK signaling and the circadian machinery and elucidate the potential role of AMPK in influencing metabolic communication between tissues, at the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), University of Copenhagen, Denmark
Postdoc in AMPK signaling in circadian metabolism
Deadline to Apply
Apr 05, 2021 23:59 (GMT +1)
No. of Position(s)
- Molecular Biology
- Molecular Biomedicine
- Circadian biology
- Mass spectrometry
According to standard norms
Staring date: October 1, 2021
Novo Nordisk Foundation Center
Basic Metabolic Research (CBMR)
University of Copenhagen
Professor Kei Sakamoto
PhD in Biology, Biochemistry, Molecular Biology, Molecular Biomedicine, or related sciences
- Knowledge of mitochondrial respiration, mammalian metabolism and circadian biology
- Documented experience with animal handling
- Demonstrated experience with mammalian tissue culture techniques and biochemical assays
- Experience with high resolution mass spectrometry and bioinformatics analysis is desirable
- The candidate should be able to work independently and interactively in a team setting, and be enthusiastic, motivated and proactive
- Excellent English communication skills, both written and oral
An essential component of an organism’s survival is the ability to sense energy availability and to adapt accordingly. As such, cells contain highly conserved sensing mechanisms that monitor energy and nutrient status. These energy sensors are tightly linked with endogenous circadian rhythms and thereby contribute to the plasticity of liver, adipose tissue and skeletal muscle to maintain metabolic homeostasis throughout the day. AMP-activated protein kinase (AMPK) is a crucial cellular energy and nutrient sensor, which integrates stimuli such as metabolites, growth factors, and energy status. Results from our group suggest that AMPK may be required as an energetic sensing mechanism controlling circadian core clock gene expression and metabolism. The main objective of this post-doctoral project is to determine the mechanism by which energetic stressors converge on AMPK signaling and the circadian machinery and elucidate the potential role of AMPK in influencing metabolic communication between tissues. The post-doctoral fellow will adopt multi-disciplinary approaches, integrating cell-based systems and animal models to validate whether AMPK pathways are involved the clock-controlled changes in systemic metabolism. This project will also include usage of transcriptomic and metabolomics platforms, as well as bioinformatics tools, and the successful candidate will therefore receive necessary basic training within these fields. Proteomics studies will be carried out in collaboration with the Deshmukh Group at the Center.
How to Apply?
Your online application must be submitted in English via the ‘Apply now’ link above. Furthermore, your application must include the following documents/attachments – all in PDF format
- Cover letter expressing the motivation and previous research experience of the applicant (max 1 page)
- Curriculum vitae
- Copy of the PhD degree certificate and the Master degree certificate. In case the PhD has not yet been completed, a written statement from the supervisor confirming it will be obtained before October 1, 2021 is acceptable.
- List of publications
- References (name and contact details of at least two references)
The Novo Nordisk Foundation Center for Basic Metabolic Research’s vision is to strengthen interdisciplinary research that transforms our basic understanding of the mechanisms that underlie metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. We were established in 2010 and in 2017, we moved into new laboratories, offices and meeting rooms in the Maersk Tower
The Center has around 240 employees who work in an international, highly collaborative research environment across a range of biomedical disciplines.
- Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated
- Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
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Post expires at 8:59am on Wednesday April 21st, 2021 (GMT+9)