CBMR Postdoc Program – Genetic studies, Obesity, Bioinformatics, Biochemistry, Molecular Biology, Biomedicine in “Genetic studies of extreme obesity in consanguineous Pakistani families”, at the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), University of Copenhagen, Denmark
Postdoc in Genetic studies of extreme obesity in consanguineous Pakistani families
Deadline to Apply
Apr 19, 2021 23:59 (GMT +1)
No. of Position(s)
- Statistical Genetics
- Molecular Biology
- Molecular Biomedicine
According to standard norms
Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), University of Copenhagen
DK-2200 Copenhagen, Denmark
Professor Torben Hansen
CBMR International Postdoctoral Program
PhD in Bioinformatics, Statistical Genetics, Biology, Biochemistry, Molecular Biology, Molecular Biomedicine, or related sciences
- Excellent scientific track record in relation to career stage
- Profound knowledge in bioinformatics and genetics
- Knowledge in metabolic diseases, especially obesity
- Experience with analysis of next generation sequence data and integration of multiple data layers
- Excellent English communication skills, both written and oral
How to Apply?
Your online application must be submitted in English via the ‘Apply now’ link above. Furthermore, your application must include the following documents/attachments – all in PDF format
- Cover letter expressing the motivation and previous research experience of the applicant (max 1 page)
- Curriculum vitae
- Copy of the PhD degree certificate and the Master degree certificate. In case the PhD has not yet been completed, a written statement from the supervisor confirming it will be obtained before October 1, 2021 is acceptable.
- List of publications
- References (name and contact details of at least two references)
With the project ‘Genetic studies of extreme obesity in consanguineous Pakistani families’, it is our ambition to perform whole genome sequencing (WGS) in 130 Pakistani families with one or more children with extreme obesity, and to identify and characterize novel obesity genes. This will generate new insights into the function of novel obesity genes and it will facilitate studies of obesity in other populations, with the perspective to improve our understanding of early stages of the development of obesity. The study will include 1) whole genome sequencing, 2) analysis of protein stability, 3) mapping obesity genes to cell types, and 4) analysis of selected loci using recessive models in other study populations.
This project will enable us to identify novel genetic variation associating with early onset obesity. We will elucidate the impact of the disease associated variants on the molecular level combining biophysical modelling of protein folding and stability with advanced sequence analyses to interpret variant effects. Furthermore, in-house initiatives to characterize open chromatin and cell type specific gene regulation will allow us to map the effect of the variants to the cellular and tissue level. Finally, we will examine whether the gene/genes associating with childhood obesity in Pakistani families might associate with obesity/BMI in other non-European populations, in Danish children with early onset obesity and in large populations based studies (i.e. UK biobank) applying recessive analytical models. The results will be used to propose and develop new approaches to diagnose, prevent and treat early onset obesity.
Your tasks would be:
1. Whole genome sequencing
In collaboration with the International Islamic University, we have collected 130 families with one or more children with severe early onset (before 5 years) obesity. All families are consanguineous and genomic DNA has been obtained from at least 3 family members (proband, mother and father). In total, we have DNA from more than 500 individuals. All families has consented to have WGS performed. Furthermore, it will be possible to re-contact families to do re-call Phenotype studies.
2. Analysis of protein stability
Together with Professor Kresten Lindorff-Larsen, Structural Biology and NMR Laboratory & Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, we will use computational methods to analyze and provide mechanistic hypotheses for identified variants in coding regions. Professor Kresten Lindorff-Larsen is PI and Torben Hansen co-PI on the PRISM (Protein Interactions and Stability in Medicine and Genomics) programme funded by the Novo Nordisk Foundation Challenge Programme.
3. Mapping obesity genes to cell types
We will capitalize on the recent CBMR flagship initiative SEGMENT – Single-cell Genomics to Map Diabetes and Obesity Heterogeneity. The single-cell omics platform at the Center has developed protocols for extraction of nuclei from frozen biopsies and can reliably isolate +10,000 nuclei/mg tissue from selected tissues for single-cell analyses. By combining chromatin accessibility with ChIP sequencing on a single cell level, you will also be able to reliably map enhancer-promoter regulation through the recently published “activity-by-contact” (ABC) model.
4. Analysis of selected loci using recessive models in other study populations
We have access to large population-based data on obesity in Denmark (n+100,000) and internationally (i.e. UK biobank). You will examine whether variations in the gene/genes associating with childhood obesity in Pakistani families might associate with obesity/BMI in other non-European populations, in Danish children with early onset obesity and in large populations based studies (i.e. UK biobank) applying recessive analytical models.
About Novo Nordisk Foundation Center for Basic Metabolic Research
The Novo Nordisk Foundation Center for Basic Metabolic Research’s vision is to strengthen interdisciplinary research that transforms our basic understanding of the mechanisms that underlie metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. We were established in 2010 and in 2017, we moved into new laboratories, offices and meeting rooms in the Maersk Tower
The Center has around 240 employees who work in an international, highly collaborative research environment across a range of biomedical disciplines.
- Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.
- Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
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Post expires at 8:59am on Tuesday April 20th, 2021 (GMT+9)