CBMR Postdoc Program – Energy, Metabolic sensing, Biochemistry, Molecular Biology to investigate the molecular and physiological roles for recently identified post-translational modifications (phosphorylation) within the regulatory subunit of AMPK, at the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), University of Copenhagen, Denmark
Postdoc in Energy/metabolic sensing, AMPK signaling
Deadline to Apply
Apr 19, 2021 23:59 (GMT +1)
No. of Position(s)
- Molecular Biology
- Molecular Biomedicine
- Metabolic research
- Human pathophysiology
According to standard norms
Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) University of Copenhagen
DK-2200 Copenhagen, Denmark
Professor Kei Sakamoto
CBMR International Postdoctoral Program
PhD in Biology, Biochemistry, Molecular Biology, Molecular Biomedicine, or related sciences
- Excellent scientific track record in relation to career stage (at least one first authored publication in an internationally recognised peer-reviewed journal)
- Profound knowledge on energy metabolism, protein kinase regulation/signalling, enzymology and biochemical assays
- Experience with preclinical studies is a plus
- Capable of working in a team, but able to plan and drive work independently
- Excellent English communication skills, both written and oral
The fellowship is aimed at early career researchers with a basic science background or clinicians who aspire to a career in academic medicine. We are particularly interested in candidates who are familiar with integrative research approaches within the broad area of basic metabolic research with an application towards human pathophysiology.
Cellular adaption to nutrient and metabolic stresses such as starvation and exercise are critical for the maintenance of organismal homeostasis. Cells have evolved tightly controlled “intra-cellular signaling systems” capable of sensing, transducing, and interpreting information such that the regulatory machinery can enact a coordinated and timely physiological response. AMP-activated protein kinase (AMPK) is an evolutionarily conserved regulator of energy homeostasis and a promising drug target for treatment of metabolic disorders. We previously identified that a tumour suppressor protein kinase, LKB1, is an upstream regulator for AMPK and demonstrated that the LKB1-AMPK pathway plays a key role in mediating “insulin-independent (energy stress-dependent)” glucose uptake and energy homeostasis in skeletal muscle. We also identified key/novel mechanism of action of small-molecule AMPK activators and provided molecular and physiological insights into their potential utility as tool compounds and future therapeutic applications. The main goal of the project is to investigate the molecular and physiological roles for recently identified post-translational modifications (phosphorylation) within the regulatory subunit of AMPK. We will undertake both in vitro and in vivo approaches (e.g. using originally generated phospho-deficient knock-in mouse models) in collaboration with world-leading groups in the AMPK field.
Your key tasks include:
- Detailed biochemical analysis of purified AMPK trimeric complex (wild-type and mutants) in the presence or absence of various agonists.
- General and specific metabolic characterizations/phenotyping of the novel AMPK genetic mouse models (as well as drug intervention studies).
- Contributions to high-standard organization of data, sample and material management
How to Apply?
Your online application must be submitted in English via the ‘Apply now’ link below. Furthermore, your application must include the following documents/attachments – all in PDF format
- Cover letter expressing the motivation and previous research experience of the applicant (max 1 page)
- Curriculum vitae
- Copy of the PhD degree certificate and the Master degree certificate. In case the PhD has not yet been completed, a written statement from the supervisor confirming it will be obtained before October 1, 2021 is acceptable.
- List of publications
- References (name and contact details of at least two references)
About Novo Nordisk Foundation Center for Basic Metabolic Research
The Novo Nordisk Foundation Center for Basic Metabolic Research’s vision is to strengthen interdisciplinary research that transforms our basic understanding of the mechanisms that underlie metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. We were established in 2010 and in 2017, we moved into new laboratories, offices and meeting rooms in the Maersk Tower
The Center has around 240 employees who work in an international, highly collaborative research environment across a range of biomedical disciplines.
- Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.
- Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
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- Postdoc Position in Biochemistry – DTU, Denmark
Post expires at 8:59am on Tuesday April 20th, 2021 (GMT+9)