Postdoc position in Fungal Communities and Secondary Metabolism, in the Center for Microbial Secondary Metabolites (CeMiSt), DTU Bioengineering, Technical University of Denmark
Deadline to Apply
Aug 01, 2021 (23: 59 GMT +1)
|No. of Position(s)||1|
|Research Area||– Comparative genomics|
|Salary||According to standard norms|
|Workplace||Center for Microbial Secondary Metabolites (CeMiSt)|
Technical University of Denmark
|Contract Period||2 Years|
|Starting date||Not mentioned|
As a formal qualification, you must hold a PhD degree (or equivalent).
We further expect that you are a team player, that can turn ideas into tangible results and have good planning skills,
It would be a big plus if you have experience with:
- Comparative genomics
- Prediction of secondary metabolite potential
- Development of assays to score fitness
We are looking for a biologist/molecular biologist/microbial ecologist with the necessary skill set for studying the composition and/or dynamics of microbial communities. We expect that you have:
- Hands-on experience with the handling and cultivation of filamentous fungi.
- Experience with standard molecular biological procedures such as DNA purification, PCR, and qPCR.
- Proven track record of publishing high-quality publications in peer-reviewed journals.
Responsibilities/ Job Description
Your primary task will be to characterize the secondary metabolite driven interactions in a mock community reflecting the fungal species found in the natural decaying apple ecosystem. The work will start with a two-species setup (Penicillium expansum and Monilinia fructigena) on agar media. Your work will further include developing tools (qPCR-based) for monitoring the species composition over time. Together, we will further analyze the metabolic dynamics (LC-MS) of the system and explore the possibilities for gene expression analysis (RNAseq) to understand the impact of secondary metabolites and potentially their mode of action.
How to Apply?
To apply, please open the link “Apply online”, fill out the online application form, and attach all your materials in English in one PDF file.
- Application (cover letter)
- Academic Diplomas (MSc/PhD)
- List of publications
- Names and contact information for two references
- H-index and ORCID (see e.g. http://orcid.org/)
- Published peer-reviewed papers (up to five), including a short description of your contribution.
About Research project
The Center for Microbial Secondary Metabolites (CeMiSt) offers a dynamic research environment full of dedicated experts covering microbiology, natural product chemistry, analytical chemistry, microbial ecology, molecular biology, and bioinformatics. The Center of Excellence includes 24 scientists from three DTU departments, and our biweekly center meetings offer the ideal environment for you to build your network, expand your scientific horizon and engage in inspiring scientific discussions.
CeMiSt focuses on answering some of the big questions within the field of secondary metabolism:
- Why do microorganisms produce secondary metabolites?
- What is the impact of secondary metabolites on microbial communities?
- How has secondary metabolism evolved?
We use three microbial ecosystems (seawater, soil and decaying apples) and rely on multidisciplinary approaches to address a similar set of questions across the systems. In the decaying apple system (few species, nutrition-rich), we have identified several key secondary metabolites, linked these to biosynthetic gene clusters, and generated both loss and gain of function mutants. The next exciting step is to test the fitness of the mutants and map the effects of losing or gaining the individual secondary metabolite for the producing organism and the community it inhabits. We hope you will join us on this journey and help with developing a suitable mock microbial community reflecting decaying apples.
About Department of Biotechnology and Biomedicine (DTU Bioengineering)
The Department of Biotechnology and Biomedicine (DTU Bioengineering) conducts research, educates future bio-engineers, provides scientific advice and innovate within the areas of microbiology, biochemistry, biotechnology and biomedicine. The research at DTU Bioengineering is at the highest international level and focuses on the societal and scientific challenges within the field. Research is conducted within three main areas: Microbial ecology and physiology, Industrial biotechnology and cell factories, and Biomedicine and health. The department has extensive collaboration with national and international research units and industries. DTU Bioengineering has approx. 250 employees, of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.
- The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.
- If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.
Associate Professor Rasmus J.N. Frandsen
Head of the Section for Synthetic Biology
Post expires at 8:59am on Monday August 2nd, 2021 (GMT+9)