Assistant Professor or Postdoc to work on organoid models for schizophrenia implementing (iPSC) in the group of “Disease Stem Cell Models and Embryology” in the Department of Veterinary & Animal Sciences, University of Copenhagen, Denmark
Deadline to Apply
May 30, 2021 (23: 59 GMT +1)
|Position||Assistant Professor or Postdoc Position|
|No. of Position(s)||1|
|Research Area||– Biology|
|Salary||According to Standard Norms|
|Workplace||Department of Veterinary and Animal Sciences|
Section for Pathobiological Sciences
University of Copenhagen
|Contract Period||39 month|
|Starting date||September 1, 2021|
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience: Essential experience and skills:
- You have a PhD in Biology, Biochemistry or similar
- You are highly experienced in stem cell culture and CRISPR/Cas9 gene editing
- You are highly experienced in differentiation of neurons and astrocytes from iPSC in 2D settings
- You are highly experienced in molecular techniques such as qRT PCR, western blotting, immunocytochemistry and electron microscopy
- You have an active interest in neurodegenerative and neurodevelopmental diseases
- You have pre- and postgraduate teaching experience within cell biology and stem cells
- You have actively supervised Bachelor and Master students
- Proficient communication skills and ability to work in teams
- Excellent English skills written and spoken
Desirable experience and skills:
- Experience in the assessment of transcriptomics and proteomics data including pathway analysis would be an asset
- Experience in electrophysiology and organoid cultures would be an asset
Responsibilities/ Job Description
- You will be dynamic researcher to work on organoid models for schizophrenia implementing induced pluripotent stem cells (iPSC) in the group of “Disease Stem Cell Models and Embryology”
- Responsible to generate iPSC from schizophrenic patients together with a project technician implementing our semi-automated robotic reprogramming platform. Subsequently, your central role will be the establishment and functional readout of air-liquid interphase cerebral organoids (CO’s). You will have the opportunity to visit Madelaine Lancaster’s laboratories at Cambridge, UK to be trained in the specific technique. Furthermore, you are expected to bridge and functionally validate the proteomics data generated by our collaborator Martin Røssel Larsen at SDU. You will have access to state-of-the-art iPSC facilities, robotic assistance in reprogramming of cells as well as multielectrode equipment for recording of network activities in the CO’s. Additionally, you will have the opportunity to participate in teaching of the iPSC PhD course and cell biology teaching to advance your teaching competencies.
The assistant professor’s responsibilities will primarily consist of:
- research, including publication/academic dissemination duties
- research-based teaching
- sharing knowledge with society
- participation in formal pedagogical training program for assistant professors
How to Apply?
To apply, please click APPLY ONLINE button mentioned above.
Your application must include the following documents/attachments – all in PDF format:
- Motivated letter of application (max. one page)
- CV incl. education, work/research experience, language skills and other skills relevant for the position
- A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do
- List of publications
- Teaching portfolio if applicable
About Research project
The research activities within the Freude group is focused on modelling and understanding neurodegenerative diseases using human induced pluripotent stem cell (iPSC). We have recently generated several iPSC models for Alzheimer’s disease (AD), Frontotemporal dementia (FTD) & Epilepsy from patient material and via CRISPR-Cas9 gene editing. Our current research is focused on brain cell type specific phenotypes in AD and FTD to gain mechanistic insights into the diseases. Our group has for example previously shown that FTD3 can be recapitulated in iPSC derived neurons and delivered new insights into neuronal disease phenotypes including metabolic defects. Our AD models display characteristic pathological hallmarks and have contributed to decipher cause and consequences in the disease pathology contributing to the identification of novel intervention points at the early disease stages.
Our collaboration with Martin Røssel Larsen and Madelaine Lancaster, relevant for this job posting, will enable the group to develop platforms for air-liquid interphase cerebral organoids and their functional assessment through mechanistic studies including state of the art multielectrode assays. Additionally, we collaborate extensively not only with local Danish scientists based at the university and industry (Lundbeck, Novo Nordisk and Bioneer A/S), but also internationally with researchers based in the USA, Brazil, India, Australia, UK, Sweden and Germany. Our group has a strong emphasis on collaborating with experts within the field and hosting international students and researchers for training in iPSC disease modelling. The long term aims of the research in Dr. Freude’s lab is to translate the in vitro results into identification of druggable targets.
- The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
- Interviews are expected to be held in June/July 2021
- Foreign applicants may find more details here International Staff Mobility
Associate Prof. Kristine Freude
Post expires at 8:59am on Tuesday June 1st, 2021 (GMT+9)