PhD Positions to study Molecular Cell Biology, Genetics, Molecular Biomedicine related to the project Neuroendocrinology and Physiology, in the Department of Biology, Faculty of Science at the University of Copenhagen, Denmark
PhD fellow in Neuroendocrinology and Physiology
Apr 15, 2021 23:59 (GMT +2)
No. of Position(s)
- Molecular Biomedicine
- Molecular cell biology
DKK 330,817 / Year
Department of Biology
Kenneth Veland Halberg, Department of Biology
Direct Phone: +45 26810458.
We are looking for a highly motivated and ambitious person who possesses most of the following qualifications:
- MSc degree in Biology, Molecular Biomedicine, Genetics, Biochemistry or similar field
- Obtained high grades/test scores
- Experience with genetics and molecular cell biology
- Experience with Drosophila or other model systems is an advantage
- Excellent communication skills in both written and spoken English
- Good interpersonal skills, well-organized and independent
Preference will be given to candidates with a record of peer-reviewed publications
- To manage and carry through your research project
- Attend PhD courses
- Write scientific articles and your PhD thesis
- Teach and disseminate your research
- To stay at an external research institution for a few months, preferably abroad
- Work for the department
How to Apply?
The application, in English, must be submitted electronically by clicking APPLY NOW above
- Cover Letter (max 2 pages), stating which PhD project you are applying for and detailing your motivation and background for applying for the specific PhD project.
- CV (max 2 pages)
- Diploma and transcripts of records (BSc and MSc)
- Acceptance Letter for the relevant MSc Programme at SCIENCE, if any
- Other information for consideration, e.g. list of publications (if any)
- 1-3 reference letters
Reference letters must be uploaded by the applicant him/herself. The recruiting person must NOT obtain reference letters which content is not known to the applicant him/herself. This is against Danish law.
About Project description
Novel mechanisms of osmosensation and systemic osmoregulation
Animals continuously face harmful changes in ion and water balance as they interact with their environment. Most organism therefore engage active osmoregulatory responses that oppose these perturbations in order to survive. These responses involve the coordinated actions of organs with specialized functions, which in turn are modulated by systemic signals communicated by other organs to ensure an appropriate physiological response by the animal. Molecular osmoreceptors lie at the heart of the mechanisms coordinating these processes. Yet, the molecular identity of such osmosensitive molecules, and how they modulate the release of known neuroendocrine factors that control systemic osmoregulation, remain unknown. In this project, we will perform an in-vivo RNAi screen to systematically uncover novel osmosensory molecules, which regulate the release of hormonal factors from cells in the brain to control systemic osmoregulation. Follow-up studies on genes of interest will further involve CRISPR-mediated genomic manipulations; live bioimaging of genetic reporters; transcriptomics; mass spectrometry analyses as well as cell and organ assays.
Description of the scientific environment
The Halberg lab at the University of Copenhagen is looking to recruit a highly talented and motivated PhD student to join our group. Our lab is interested in how endocrine messengers (neuropeptides and hormones) coordinate organ functions by relaying information about the internal state or external environment in a manner that allows the organism to adapt and survive. We use the model organisms Drosophila melanogaster and Tribolium castaneum to explore these questions because they allow us to adopt an integrative approach; we use genetic and molecular tools to interfere with the function of molecules, cells or organs in order to study the impact on the whole organism. Beyond gaining insights into the basic underpinning biology, our research may be important for understanding human diseases and for developing novel insect pest control agents.
- Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.
- The starting salary is currently at a minimum DKK 330,817 (approx. €44,108) including annual supplement (+ pension at a minimum DKK 53,761). Negotiation for salary supplement is possible.
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Post expires at 8:59am on Friday April 16th, 2021 (GMT+9)