Postdoc Position in Endoscopic Two-Photon Light Sheet Imaging for Colon Cancer Diagnosis is available at the Department of Health Technology, Technical University of Denmark, Denmark.(Bioimaging, Colon Cancer Diagnosis – Physics, Optics Degree – Jobs for Physics PhD)
Deadline to Apply
May 05, 2021 (23: 59 GMT +1)
|No. of Position(s)||1|
|Research Area||– Physics|
– Health Technology
|Salary||According to standard norms|
|Workplace||Biophotonic Imaging group |
Department of Health Technology,
Technical University of Denmark,
|Contract Period||2 Year|
|Starting date||Jun 01, 2021|
- PhD degree in Physics or equivalent.
- You must be familiar with designing, constructing and aligning optical setups, and you must have a solid theoretical background in optics.
- You must have skills in programming, modelling, data acquisition and analysis.
- We expect you to be self-driven and to take a lead in the above tasks, and to actively contribute with your own ideas and research interests to the overall aim of the project.
- We expect you to be comfortable collaborating with other people and research groups and to take responsibility for your work.
Responsibilities/ Job Description
- You are comfortable with supervising students on the master and PhD level, and take pride in graduating excellent students.
- Your goal will be to implement two-photon excited fluorescence light sheet microscopy into an endoscopic probe head, characterise its performance, and apply it in a proof of concept in vivo study.
The project includes the following tasks, to which you will substantially contribute:
- designing and testing different light sheet illumination schemes based using beam shaping with an SLM and micro-optical elements;
- designing and testing different image data collection options, such as commercially available miniaturized camera chips, fibre bundles or scanned collection;
- characterising imaging performance of said imaging on in vitro tissue models in terms of imaging depth, field of view and SNR;
- implementing code to analyse and characterise the gathered images using both conventional algorithms and machine learning, with the aim to provide quantitative information relevant for diagnosis;
- combining your findings in a multimodal approach with OCT and Raman spectroscopy images gathered on our and our partners’ microscopes, to show further improved accuracy;
- apply the above findings in a proof of concept in vivo study
- All the above tasks are a collaborative effort with other PROSCOPE partners. The illumination and image collection schemes are a close collaboration with IMTEK at the University of Freiburg and GRINTECH GmbH, the image analysis and characterisation are conducted in collaboration with the University of St. Andrews.
How to Apply?
To apply, please open the link “Apply online”, fill out the online application form, and attach all your materials in English in one PDF file.
Applications must be submitted as one PDF file containing all materials to be given consideration. The file must include:
- Application (cover letter)
- Academic Diplomas (MSc/PhD)
- List of publications
About Research project
Colorectal cancer is the second most common cause of cancer death in Europe, causing 225 000 deaths in 2012 (12% of the total) . Current standard practice for diagnosing colorectal cancer is white light endoscopy, during which the colonoscopist assesses the appearance of polyps and tissue to identify possible neoplastic changes and decides whether to resect for further analysis using histopathology. To avoid a high number of undetected early stages of colorectal cancer, this procedure results in many unnecessary resections, posing higher risk for colon perforation requiring emergency surgery. On top of this, colonoscopy is not as effective in prevention of colorectal cancer in the right colon as in the left and provides sensitivity and specificity levels starting at 60% and 40% .
Therefore, a technology to assess the malignancy of suspect lesions in situ during colonoscopy would benefit both the patients and reduce healthcare costs. Optical imaging modalities can non-invasively probe tissue using non-ionizing radiation. This makes optical imaging an obvious choice for use as a diagnostic tool in many fields in healthcare, including oncology.
Your work is part of the European project “PROSCOPE” (www.proscope-h2020.eu), funded by H2020, where we develop a classification tool for in vivo colon cancer diagnosis based on multimodal optical images in collaboration with European project partners.
About the Department
The Postdoc will join the Biophotonic Imaging group consisting of approx. 10 employees, including several PhD students and postdocs. Within the group, we are working on the advancement of optical imaging technologies for clinical and biological applications. Currently we have research projects on multimodal imaging combining optical coherence tomography, two-photon excitation fluorescence microscopy, light sheet microscopy, optical probe head development, fibre delivery of ultrashort pulses, and investigation of biomarkers relevant for cancer diagnosis using biophotonic imaging.
- If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.
- All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.
Tel.: +45 4677 4568
Peter E. Andersen
Tel.: +45 4677 4555
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